HuDA_COVID Human Disposition Analysis During COVID-19 Using Machine Learning

Coronavirus has greatly impacted various aspects of human life, including human psychology and human disposition. In this paper, the authors analyzed the impact of the COVID-19 pandemic on human health. In the proposed work, human disposition analysis during COVID-19 using machine learning (HuDA_COVID), where factors such as age, employment, addiction, stress level are studied. A mass survey is conducted on individuals of various age groups, regions, and professions, and the methodology achieved varied accuracy ranges from 87.5% to 98%. The study shows people are worried about lockdown, work, and relationships. Furthermore, 23% of the respondents have not had any effect. Forty-five percent and 32% have had positive and negative effects, respectively. HuDA_COVID is a novel study in human disposition analysis in COVID-19 where a weighted assignment indicating the health status is also proposed. HuDA_COVID clearly indicates a need for a methodical approach towards the human psychological needs to help the social organizations formulating holistic interventions for affected individuals.

Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19*

Myricetin (3,5,7,3 ',4 ',5 ' -hexahydroxyflavone), a common dietary flavonoid, has been reported for its roles in improving health due to various pharmacological activities, such as antioxidant, antimicrobial, anti-inflammatory, analgesic, antitumor, hepatoprotective, and antidiabetic. Myricetin has also been shown to have a broad spectrum of antiviral effects against a variety of viruses including Rauscher murine leukemia virus (RLV), human immunodeficiency virus (HIV), Coxsackie virus, Ebolavirus, Zika virus, herpes simplex virus (HSV-1 and HSV-2), dengue virus, murine norovirus, infectious bronchitis virus, African swine fever virus, and both DNA polymerase alpha and DNA polymerase I. Intensive research suggests that the remarkable potential of myricetin in promoting either the prevention or overcoming of SARS-CoV-2 infection is due to the wide range of its effects on SARS-COV-2 proteases, including modulation of inflammatory processes and immune responses. In silico and in vitro studies demonstrated that myricetin can effectively interfere at various stages of viral infection, including the coronavirus entry and replication cycle due to its high-binding affinity with S-protein, ACE2 receptor, PLpro, Mpro, RdRp, exonuclease, and endoribonuclease. Based on the findings discussed in this review, myricetin, its glycosides, and dihydromyricetin, can be considered as multi-targeted agents having beneficial effects in combatting COVID-19.

Phytochemicals Against SARS-COV-2 Infection

Natural Product Communications Special Collection "Phytochemicals against SARS-COV-2 Infection" accepted 13 manuscripts, represented by 2 reviews, 9 original articles, and 1 letter to the editor. These deal with the use of traditional medicines, the use of network pharmacology, and docking studies to identify active compounds with prominent binding to various receptors responsible for internalization and replication, such as ACE2, S-protein, Mpro, PLpro, RdRp, and NSP15 endoribonuclease, as well as the possible use of phytochemicals against virus-associated inflammation. Copyright © The Author(s) 2023.

Paediatricians' perspectives regarding breastfeeding during the Covid-19 pandemic: A cross-sectional study

Introduction: Covid-19 pandemic has raised queries regarding implications for breastfeeding (BF). Data are limited and recommendations for initial days after birth differ. Parents count on paediatricians for optimal information about feeding their infants, especially when the mother is infected. Objectives: To estimate knowledge of paediatricians about BF in suspected or confirmed maternal cases of Covid-19, its association with demographic variables, and participants' opinions about factors influencing their guidance to parents regarding infant nutrition in Covid-19 infected mothers. Method: This was a prospective cross-sectional study based on an online questionnaire administered to paediatricians in Uttar Pradesh, India, from February to March 2021. A total of 389 paediatricians participated. Knowledge questions were based on the World Health Organization guidance on BF for Covid-19. Results: Among the 389 participants, 44.5% had adequate knowledge, 38.3% had average knowledge, and 17.2% had inadequate knowledge;96.4% paediatricians preferred mothers' milk for infants with Covid-19 infected mothers. Fear of transmission of infection to infant was the major restraint, while the low risk of transmission to the infant if infection prevention and control practices were followed was the most useful factor perceived while counselling an infected mother for BF.Conclusions: Knowledge of paediatricians about BF in suspected or confirmed maternal cases of Covid-19 was adequate in 44.5%, average in 38.3% and inadequate in 17.2%. Majority (96.4%) of paediatricians favoured BF in maternal Covid-19 cases. © 2022,Sri Lanka Journal of Child Health. All Rights Reserved.

A Retrospective Observational Study of Neurological Manifestations in COVID-19 (SON-CoV)

Objectives: Coronavirus disease 2019 (COVID-19) has neurologic manifestations associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to retrospectively analyze SARS COVID-19 patients with neurological manifestations and identify patterns of presentation including the site of neuroaxis involvement, neuroimaging, and associated systemic involvement. Methods and subjects: This retrospective observational study was conducted at two tertiary care hospitals in western Rajasthan. Data on age, sex, presenting symptoms, and comorbidities (hypertension, diabetes, cardiac, cerebrovascular disease, and cancer) were collected from 28th February 2020 to 31st December 2020 through medical records, discharge summaries, and radiological studies. Verbal/written patient consent was obtained due to the prevailing COVID-19 norms at the time of the first wave. Major inclusion criteria were as follows: age >18 years, consent from patient/surrogate, positive RT-PCR report in case of active COVID cases, or positive COVID antibody test in case of post-COVID neurological sequelae. All neurological manifestations were reviewed by at least two neurologists and were divided into central nervous system (CNS) and peripheral nervous system (PNS) manifestations. Systemic features and their temporal relationship with neurological features were recorded. Various other specialized assessments and therapeutic interventions were conducted. Statistical analysis was performed using the SPSS software. A Chi-square test was performed to determine the association between variables. Student's t-test and one-way analysis of variance were used to determine differences in mean values. Statistical significance was set at p < 0.05. Results: The mean age was 57.32 years for the CNS group and 40 years for the PNS group (p = 0.025). Age was significantly lower in the PNS group than in the CNS group (p = 0.025). Anemia, leucocytosis, and elevated serum creatinine were more commonly seen in the CNS group, although the difference was not statistically significant. The most common CNS manifestations were stroke (41.8%), of which ischemic stroke constituted 83% of cases, followed by seizure (22%), encephalopathy (20.9%), headache (15.1%), and vertigo (3.8%). The most common PNS manifestation was neuropathy (57%), which included Guillain-Barré syndrome (GBS), critical illness neuropathy, and autonomic neuropathy. Conclusion: CNS symptoms of COVID-19 are more common than PNS symptoms. Stroke is the most frequent (46%) COVID-CNS symptom, which occurs in people of age above 35 years and is associated with high mortality. © The Author(s). 2022Open Access This article is distributedunder the terms ofthe Creative Commons Attribution 4.0InternationalLicense (https://creativecommons.org/licenses/by-nc/4.0/)

How Special is New Year Eve Traffic? Insights from Four Years 3G/4G/5G User Measurements

The specialness of New Year eve traffic is a telecoms industry fable. But how true is it, and what's the impact on user experience? We investigate this on the four UK cellular networks, in London, on New Year eve in 2016/17, 2017/18, 2018/19 and 2019/20 (covid cancelled 2020/21 & 2021/22). Overall, we captured 544,560 readings across 14 categories using 3G/4G/5G devices. This paper summarises our longitudinal readings into 10 observations on the nature of network performance, from a user's perspective, on special days such as New Year eve. Based on these, we confirm that mature 3G/4G networks are unable to deliver a consistent user experience, especially on atypical days. For example, on 4G, a user had a 60% chance to get a latency below 50 ms and 90% chance for 500ms. If repeated in mature 5G networks, it suggests that it is inadequate to support safety-critical 5G use cases. © 2022 IEEE.

COVID-19 curve exploration using time series data for India

Considering the ongoing pandemic of Coronavirus disease which has engulfed almost the entire world, it has become vitally important to predict the outbreak of the virus in the coming days using appropriate algorithms. Forecasting the cases will aid healthcare in prompting policies to control the disease. This chapter aims to analyze the trend pattern of COVID-19 with the help of different prediction models. In this chapter, we used time series models to analyze the real-world time series data of COVID-19 cases for India. The analysis shows that the ARIMA model has proved to be more effective for forecasting COVID-19 prevalence. © 2022 Scrivener Publishing LLC.

A Family-based Child Health Education Curriculum for Refugee Families

Background: Refugees are at risk for low health literacy and high rates of illness and hospitalization. A partnership between medical professionals at Yale and two New-Haven, CT-based refugee resettlement organizations aimed to create and implement a family-based, interactive pediatric healthcare curriculum with a goal of increasing childhood health knowledge among refugee families. Methods: Seven 1-hour, in-person classes and 1 virtual class were taught by pediatric residents with real-time translation in Pashto, Dari, Arabic, Swahili, and Kinyarwanda on the topics of child nutrition, safety, parenting, and oral health. Each class incorporated play-based activities for toddlers-a My Healthy Plate puzzle, street-crossing simulation, teeth-brushing demonstration, and block play-which were integrated into parental discussion with visual aids. Knowledge acquisition and satisfaction was assessed using pre- and posttests. Results: 67 adult participants had an 85% response rate. Average knowledge test scores increased in 5 of 7 classes, reaching significance in a class on parenting (mean 52% vs 90%, paired t-test p = 0.03) and child safety (mean 80% vs 97%, p = 0.04). 100% of respondents (67% response rate) reported increased understanding of the topic and would recommend the class to a friend. There were 5 participants for the virtual class. Conclusion: Child health education classes conducted for refugee families can improve knowledge of pediatric healthcare topics and provide positive experiences. A close relationship between healthcare providers and community refugee organizations has the potential to improve health education in refugee families. Future studies will assess efficacy and satisfaction of virtual classes during the COVID-19 pandemic.

A Novel Multi-Objective Nonlinear Discrete Binary Gaining-Sharing Knowledge-Based Optimization Algorithm: Optimum Scheduling of Flights for Residual Stranded Citizens Due to COVID-19

GSK algorithm is based on the concept of how humans acquire and share knowledge through their lifespan. Discrete binary version of GSK named novel binary gaining sharing knowledge-based optimization algorithm (DBGSK) depends on mainly two binary stages: binary junior gaining sharing stage and binary senior gaining sharing stage with knowledge factor 1. These two stages enable BGSK for exploring and exploitation of the search space efficiently and effectively to solve problems in binary space. One of these practical applications is to optimally schedule the flights for residual stranded citizens due to COVID-19. The problem is defined for a decision maker who wants to schedule a multiple stepped trip for a subset of candidate airports to return the maximum number of residuals of stranded citizens remaining in listed airports while comprising the minimization of the total travelled distances for a carrying airplane. A nonlinear binary mathematical programming model for the problem is introduced with a real application case study. The case study is solved using DBGSK.

Menstrual Cycle Changes after COVID-19 Infection: Does Coronavirus-induced Stress Lead to Hormonal Change?

Background: Pieces of clinical evidence suggest that coronavirus disease-2019 (COVID-19) viral infection results in hormonal imbalance leading to changes in menstrual cycles of women. This study has been conducted with the aim to determine the effect of COVID-19 infection and its vaccine on menstrual cycle patterns. Materials and methods: This was a cross-sectional study to observe any changes in menstrual cycle after COVID-19 infection or after its vaccination. A Web Link collector generated the survey‘s universal resource locator (URL) and was sent via social media messages to females in the general population as well as healthcare workers. Results: Menstrual cycles remained unaltered in 154/228 (67.5%) of women post-COVID-19 infection irrespective of its severity. Out of 228, one-third of women, i.e., 74/228 (33%), reported changes in their menstrual patterns, with respect to either cycle length, duration of flow, number of pads used, pain during menses, or premenstrual symptoms (PMSs). Menstrual blood loss was decreased by 14% (32/228) and 18%;42 women complained of increased flow during menses. Twenty percent of women who had severe infections had menorrhagia. Out of the 590 women who completed the questionnaire, 436 (73.8%) were vaccinated against COVID-19 and 154 (26%) were unvaccinated. After vaccination, 290/436 around one-third of women (66.5%) had normal menstrual cycle, 21 women (4.8%) had decreased menstrual blood flow, and 18 women (4.1%) reported increased menstrual flow. Conclusion: COVID-19 infection affected the menstrual cycle of only one-third of women and this effect was temporary. This effect might be due to stress and anxiety affecting the hypothalamic-pituitary axis (HPA). More studies are needed to support this effect.

Leukemoid reaction in a patient with COVID-19 infection: A case report

Rationale: COVID-19 usually presents with flu-like symptoms and signs, but some rare presentations like leukemoid symptoms cannot be ignored. Patient's concerns: A 37-year-old female presented to the outpatient department with flu-like symptoms. Diagnosis: The RT-PCR test for SARS-CoV-2 infection was positive, while complete blood cell and peripheral blood smear showed leukemoid reaction. Intervention: Paracetamol and fexofenadine for flu-like symptoms and leukemoid presentation. Outcomes: On the 10th day, the patient was asymptomatic and RT-PCR was negative. So the patient was discharged and leukemoid presentation subsided after clearance of viral disease. Lessons: COVID-19 has a myriad of presentations, and unusual symptoms/signs especially in this pandemic could be induced by COVID-19 infection.

Prospective Randomized Double-blind Placebo-controlled Study to Assess the Effects of Nano-ozonized Hydrogen Peroxide Nebulization on Results of RTPCR for Novel Coronavirus thus Infectivity and Clinical Course among Moderately Sick COVID-19 Patients Hope in COVID-19 (Hydrogen Peroxide Inhalation)

Importance: Given the high mortality and cost of health care, especially in isolation settings, the idea of using nebulized hydrogen peroxide may play a very significant role in inactivation of coronavirus, thus reducing the infectivity period leading to reduced requirement of isolation and improving morbidity and mortality in people suffering with coronavirus disease-2019 (COVID-2019). Aim and objective: Objective of this study was to determine the efficiency of nebulized hydrogen peroxide (H2O2) in reducing the viral load and disease severity of patients suffering with COVID-19. Design: Double-blinded randomized control trial. HOPE in COVID-19 study. Setting: Tertiary care COVID hospital (single center). Participants: Moderate sick COVID-19-positive patients were included in the study after they qualified the inclusion criteria. Intervention: Patients were nebulized using 1 mL of ozonized 3% H2O2 after diluting with 4 mL of normal saline three times a day for 5 days. The control group was nebulized with normal saline only. Main outcome: Outcome was assessed for reduction in oxygen requirement (number of days on oxygen), symptoms resolution (dyspnea, cough, and fever), and number of days it took to be RT-PCR negative for COVID-19. Results: The early data from trial showed promising trends toward a better outcome. The study showed that in the case group who were nebulized with hydrogen peroxide resulted in better outcome in terms of parameters assessed in the study and the differences from the control group were statistically significant (p ≤0.001, CI 95%). Outcome in the form of mortality (odds ratio 0.29, 95% CI 0.02–3.14, p = 0.31, z = 1.007) was statistically insignificant. The number needed to treat for our study was 10.

Impacts and Implications of COVID-19: An Analytical and Empirical Study

Impacts and Implications of COVID-19: An Analytical and Empirical Study describes the most recent research developments regarding COVID-19. This book includes a wide range of interdisciplinary submissions that address the latest findings regarding a wide variety of psychological, social, managerial, and technological issues for fighting COVID-19. Chapter One discusses how machine learning applies to prediction, forecasting, screening, contact tracing, treatment, medication and the drug or vaccine invention process in connection with COVID-19. Chapter Two deals with immunomodulatory therapy for clinical management of COVID-19 patients. Chapter Three describes the importance of social distancing and the development of a tool to detect social distancing. Chapter Four discusses the impact of COVID-19 on the education sector, and Chapter Five focuses on the impacts of COVID-19 on employment, e-commerce, and e-pharmacies. Chapter Six gives an insight into the policies regarding COVID-19 in India, and Chapter Seven compares vaccine candidates based on their status in trial phases, route of administration, dosage, efficacy, and safety. Chapter Eight explores how the pandemic has impacted human communication and relationships, as people have been forced to interact in the digital space rather than the physical one. Chapter Nine describes the urgent need to devise sustainable and effective strategies to mitigate the problems relating to shortages of labor and equipment in the agricultural sector due to the pandemic. Finally, Chapter Ten describes the role of physical therapy in the recovery of COVID-19 patients. © 2021 by Nova Science Publishers, Inc. All rights reserved.

Impact of COVID-19 on lifestyle and education

COVID-19 or coronavirus or novel coronavirus, whatever the name is, becomes a buzz in the year 2020, which made the whole world prison and cost several lives. It disturbed the countries' economies and made it fall like a house of cards, and several people lost their jobs, income sources, and it has been a penalty for several students. Several organizations got affected, and some organizations shut down entirely where some of the organizations gained huge profits. This chapter performed a rigorous study to know how salaried people and students' lives are affected during this pandemic. We will also discuss what kind of significant changes came into the entire world's education system, how did this pandemic affect the jobs around the world, and how did it create opportunities for new businesses at the same time to grow. © 2021 Nova Science Publishers, Inc.

Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19

Naringenin, widely distributed in fruits and vegetables, is endowed with antiviral and other health beneficial activities, such as immune-stimulating and anti-inflammatory actions that could play a role in contributing, to some extent, to either preventing or alleviating coronavirus infection. Several computational studies have identified naringenin as one of the prominent flavonoids that can possibly inhibit internalization of the virus, virus-host interactions that trigger the cytokine storm, and replication of the virus. This review highlights the antiviral potential of naringenin in COVID-19 associated risk factors and its predicted therapeutic targets against SARS-CoV-2 infection.

Association of COVID-19 with Mucormycosis-An Appalling and Enervating Disease in North West India

Introduction: The pandemic Coronavirus Disease 2019 (COVID-19) continues to be a significant problem worldwide. The disease pattern ranges from mild to life threatening pneumonia. Association of COVID-19 with mucormycosis is rare but an increase in this association has been observed recently, particularly in a background of immunocompromised state with rhino-orbital-cerebral region being the most common site of involvement. Aim: To study the site and presentation of mucormycosis in COVID-19 patients with histopathological association. Materials and Methods: A descriptive study was conducted at American International Institute of Medical Sciences, Udaipur, Rajasthan, India, in which 1st 20 patients of COVID-19 with mucormycosis of rhino-orbital region were included in the study. The study was conducted for a period of two months (April-May 2021). Detailed clinical history and associated co-morbidities were noted for each patient. Histopathological examination of all the specimens resected for fungal infection was done along with special stain. Statistical analysis was done using Chi-square test. Results: COVID-19 association with mucormycosis was observed in all 20 cases. Maximum number of cases (11) was present in the age group of 20-40 years. Diabetes Mellitus (DM) had a strong association with mucormycosis. Maxillary sinus was most commonly associated site. Preoperative Potassium Hydroxide (KOH) was positive in all 20 cases, detailed histopathology study along with Periodic Acid Schiff (PAS) stain was performed in all cases. Additional microscopic findings like angioinvasion (03), granuloma (01) and giant cell reaction (13) were also recorded. Conclusion: COVID-19 has emerged as a global threat to mankind. In the present scenario the entire medical fraternity should have a prompt and team approach towards the management of this pandemic, in terms of, early detection of the infection, meticulous use of corticosteroids and screening of comorbidities to safeguard patients from such life threatening fungal infections.

Disinfection Measures during COVID-19

Corona illness 2019 (covid-19) has been occured by widspread serious lung condition due to infection with newly emerging Corona virus 2 during 2019. The infection threatened people health world-wide. Covid2-19 started in China and caused an aggregate of few affirmed cases and few of them passing till end of sixth month. Infection occurs essentially through lung droplets and infect near by people. Individual to-individual infection occur by conveyance by droplets from hack, wheeze, drop inward breath, and infection through upper dry epithelium polluted by emissions of complete respiratory tract system of a infected individual had been demonstrated about corona spread. As infection advanced, a progression of intricacies will in general grow, particularly in fundamentally sick and immunocompromised patients. Neurotic investigations demonstrated delegate highlights of intense lung misery condition (ARDS) and involvement of different organs too. Nonetheless, no particular antiviral medications or immunizations are promptly accessible to the medical care of this deadly infection. The adequacy of some encouraging antibacterial should be examined to continuous health preliminaries. In this conditions, strong consideration, safety measures, and physical distansing are the lone preventive measuresfor protection against CORONA. To sanitize the climate, fundamentally compound bactericidal are being utilized powerfully. Notwithstanding, because of frenzy state, fear, and ignorance, individuals are utilizing it fiercely, which can adversely affect human wellbeing and climate. This audit examines the likely negative impact of disinfectants, whenever utilized improperly. Here, we will likewise talk about safe preventive choices as an option in contrast to strong utilization of sterilization strategies to battle against CORONA.